Dive into the flavors of the South with this delicious catfish po boy recipe. Crispy, golden catfish fillets are paired with fresh lettuce, juicy tomato slices, and a zesty sauce on toasted french bread rolls. It's a perfect blend of textures and tastes that will transport you straight to New Orleans.
While most of the ingredients for this recipe are common, you might need to pay special attention to catfish fillets and cajun seasoning. Catfish may not be available in all supermarkets, so check the seafood section or ask the fishmonger. Cajun seasoning is a spice blend that can usually be found in the spice aisle, but if not, you can make your own with a mix of paprika, garlic powder, onion powder, cayenne pepper, and other spices.

Ingredients for Catfish Po Boy Recipe
Catfish: A mild-flavored fish that is perfect for frying and holds up well in sandwiches.
Cornmeal: Adds a crunchy texture to the fried catfish.
All-purpose flour: Helps to create a crispy coating when combined with cornmeal.
Cajun seasoning: A blend of spices that adds a kick of flavor to the catfish.
Buttermilk: Used to moisten the catfish fillets before dredging in the cornmeal mixture.
French bread rolls: The base of the sandwich, providing a crunchy and chewy texture.
Lettuce: Adds a fresh, crisp element to the sandwich.
Tomato: Provides juiciness and a slight acidity to balance the flavors.
Mayonnaise: The base for the sauce, adding creaminess.
Hot sauce: Adds heat and tang to the mayonnaise, creating a zesty sauce.
Technique Tip for This Recipe
When frying the catfish, ensure the oil is at the right temperature by using a thermometer. The ideal temperature is around 350°F. If the oil is too hot, the catfish will burn on the outside before cooking through. If it's too cool, the catfish will absorb too much oil and become greasy.
Suggested Side Dishes
Alternative Ingredients
catfish - Substitute with tilapia: Tilapia has a mild flavor and similar texture, making it a great alternative to catfish.
cornmeal - Substitute with panko breadcrumbs: Panko breadcrumbs provide a similar crispy texture when fried.
all-purpose flour - Substitute with rice flour: Rice flour can give a similar coating and is also gluten-free.
cajun seasoning - Substitute with creole seasoning: Creole seasoning has a similar blend of spices and can provide the same flavor profile.
buttermilk - Substitute with plain yogurt: Plain yogurt can mimic the tanginess and thickness of buttermilk.
french bread rolls - Substitute with hoagie rolls: Hoagie rolls have a similar texture and size, making them a good alternative.
shredded lettuce - Substitute with shredded cabbage: Shredded cabbage provides a similar crunch and can hold up well in a sandwich.
tomato - Substitute with roasted red peppers: Roasted red peppers add a sweet and slightly smoky flavor as a substitute for fresh tomatoes.
mayonnaise - Substitute with greek yogurt: Greek yogurt can provide a creamy texture with a bit more tang and less fat.
hot sauce - Substitute with sriracha: Sriracha offers a similar level of heat and a slightly different but complementary flavor.
Other Alternative Recipes
How to Store / Freeze Your Dish
- For short-term storage, place the catfish fillets in an airtight container and refrigerate for up to 2 days. Ensure the catfish is completely cooled before storing to prevent condensation and sogginess.
- To freeze the catfish fillets, first allow them to cool completely. Wrap each fillet individually in plastic wrap, then place them in a freezer-safe bag or container. Label with the date and freeze for up to 3 months.
- When ready to reheat, thaw the catfish fillets in the refrigerator overnight. For a quicker method, place the wrapped fillets in a bowl of cold water until thawed.
- Reheat the catfish fillets in a preheated oven at 350°F (175°C) for about 10-15 minutes, or until heated through. This helps maintain the crispy texture.
- Store the french bread rolls in a bread box or a sealed plastic bag at room temperature for up to 2 days. For longer storage, freeze the rolls in a freezer-safe bag for up to 3 months.
- Keep the shredded lettuce and sliced tomato in separate airtight containers in the refrigerator. Use within 2-3 days for optimal freshness.
- The mayonnaise and hot sauce mixture can be stored in an airtight container in the refrigerator for up to a week. Stir well before using.
- When assembling the Catfish Po Boy after storage, ensure all components are fresh and properly reheated. Toast the french bread rolls again if necessary to restore their crispiness.
How to Reheat Leftovers
Preheat your oven to 350°F. Place the catfish fillets on a baking sheet lined with parchment paper. Cover them loosely with aluminum foil to prevent drying out. Bake for about 10-15 minutes, or until heated through.
For a quicker method, use a toaster oven. Set it to 350°F and place the catfish fillets inside. Heat for 8-10 minutes, checking occasionally to ensure they don't overcook.
If you prefer using a microwave, place the catfish fillets on a microwave-safe plate. Cover them with a damp paper towel to retain moisture. Heat on medium power for 1-2 minutes, checking and flipping halfway through.
To reheat the French bread rolls, wrap them in aluminum foil and place them in a preheated oven at 350°F for about 5-7 minutes, or until warm and slightly crispy.
For the sauce, simply give it a good stir and let it come to room temperature. If you prefer it warm, you can microwave it for 10-15 seconds.
Reassemble your Catfish Po Boy by spreading the reheated sauce on the warmed French bread rolls, adding the reheated catfish fillets, and topping with fresh shredded lettuce and sliced tomato. Enjoy your revitalized sandwich!
Best Tools for This Recipe
Mixing bowl: Use this to combine the cornmeal, flour, and cajun seasoning.
Frying pan: Essential for frying the catfish fillets to a golden brown.
Tongs: Handy for flipping the catfish fillets in the pan without breaking them.
Spatula: Useful for removing the catfish fillets from the frying pan.
Measuring cups: Necessary for measuring out the cornmeal, flour, buttermilk, and mayonnaise accurately.
Knife: Needed for slicing the tomato.
Cutting board: Provides a safe surface for slicing the tomato.
Toaster or oven: Used to toast the French bread rolls.
Small bowl: Ideal for mixing the mayonnaise and hot sauce to make the sauce.
Paper towels: Useful for draining the excess oil from the fried catfish fillets.
Plate: For assembling the sandwiches and serving.
How to Save Time on This Recipe
Prepare ingredients in advance: Measure and mix the cornmeal, flour, and cajun seasoning ahead of time. Store in an airtight container.
Use pre-shredded lettuce: Save time by buying pre-shredded lettuce instead of shredding it yourself.
Pre-slice tomatoes: Slice the tomatoes and store them in the fridge until you’re ready to assemble the sandwiches.
Make the sauce ahead: Mix the mayonnaise and hot sauce in advance and keep it refrigerated.
Toast rolls simultaneously: Toast the french bread rolls in the oven while frying the catfish to save time.

Catfish Po Boy Recipe
Ingredients
Main Ingredients
- 4 fillets Catfish about 6 oz each
- 1 cup Cornmeal
- 1 cup All-purpose flour
- 1 teaspoon Cajun seasoning
- 1 cup Buttermilk
- 4 French bread rolls split and toasted
- 1 cup Shredded lettuce
- 1 Tomato sliced
- ½ cup Mayonnaise
- 1 tablespoon Hot sauce
Instructions
- 1. Mix the cornmeal, flour, and Cajun seasoning in a bowl.
- 2. Dip catfish fillets in buttermilk, then dredge in the cornmeal mixture.
- 3. Heat oil in a frying pan over medium-high heat. Fry catfish until golden brown, about 3-4 minutes per side.
- 4. Mix mayonnaise and hot sauce to make the sauce.
- 5. Assemble the sandwiches: spread sauce on toasted rolls, add catfish, lettuce, and tomato slices.
Nutritional Value
Keywords
Suggested Appetizers and Desserts
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